Monkeypox Testing updates

Hi everyone - Labcorps has apparently started testing - not sure about other labs. CDC reporting guidance for monkeypox is here https://www.cdc.gov/poxvirus/monkeypox/lab-personnel/report-results.html

Has anyone received ELR yet? Any issues?  

Thank you!

Hi Annie!
Mayo let states know they are waiting for final CDC validation to start offering their testing. I believe they expect that this week.

Wendy from Quest is ooo until tomorrow. I haven't heard any updates myself; not sure if others have.

On Thursday call with APHL, there was discussion on how Sonic Healthcare was going to report as they are using a different lab than where their covid testing is being done? Everyone was looking for any MPX results to come via AIMS as covid is now. 

Aegis is still in development last I heard.

Others please add their updates. thank you

Just received CDC press release that Mayo is starting today

Hi Nicole, thanks! No LOINC or SNOMEDs posted yet from Quest. 

Just received from Quest

Quest Diagnostics Order Code = 12084 Monkeypox DNA, Qualitative, Real Time PCR

 | Local Test Code | Test Desc | LOINC | LOINC Desc
| 86032769 | ORTHOPOXVIRUS DNA, QL PCR | 100434-0 | Orthopoxvirus.non-variola DNA [Presence] in Specimen by NAA with probe detection
| 86032770 | MONKEYPOX VIRUS DNA, QL PCR | 100383-9 | Monkeypox virus DNA [Presence] in Specimen by NAA with probe detection

 

We will be using these SNOMED codes for the results:

 

Detected             260373001

Inconclusive       419984006

Equivocal             42425007

Not detected     260415000

From the Mayo ELR Workgroup Meeting Minutes email on 7/13 afternoon -
 

| Result ID | Result Name | LOINC Value
| 618596 | Orthopoxvirus DNA, PCR | 100434-0

| SNOMED Definition | 
| Test Code | SNOMED Code | SNOMED Code Description
| 618596 | 260373001 | Detected
| 618596 | 260415000 | Undetected
| 618596 | 419984006 | Inconclusive
| 618596 | 42425007 | Equivocal

 

Latest from Aegis Labs-
 
We will be following the CDC guidance for reporting results found here. We will be utilizing LOINC 100434-0 for Non-variola Orthopoxvirus and the applicable SNOMED codes defined in the CDC guidance.  Our intent is to report these results using the existing COVID-19 format that we currently maintain together.  If you are also aware of a need for Monkeypox testing for your Department of Health, please feel free to reach out to info@aegislabs.com, and our Client Relations team will be in touch to see how Aegis can support your teams’ efforts.

 

If you have any questions in the meantime, please send them to the following representatives within our organization:

•             Josh Schrecker – Joshua.schrecker@aegislabs.com

•             Benjamin Salazar -  benjamin.salazar@aegislabs.com

•             Neal Goodwin - neal.goodwin@aegislabs.com

 

| Target | Specimen Description | Specimen SNOMED | Ordering / Test Performed LOINC | Resulting LOINC | Result Options | Result SNOMED
| Non-Variola Orthopoxvirus | Lesion Dry Swab | 472862007 | 100434-0 | 100434-0 | Positive | 260373001
| Equivocal | 42425007
| Inconclusive | 419984006
| Negative | 260415000

Thanks Abhilasha!

although those are the SNOMEDs for Detected and Not Detected LOL

Has anyone had an update on Sonic for testing? We are really struggling to find an appropriate contact for monkeypox testing.

Sonic is planning on sending monkeypox results through the AIM feed shortly. We will update when they start sending.

Doug - Rikki mentioned that the Quest monkeypox virus PCR test would need a new LOINC code - has that been assigned yet?

Thanks!

Nancy,

Yes. Here is what they should be using:

LOINC - 100888-7

Long Common Name - West African monkeypox virus DNA [Presence] in Specimen by NAA with probe detection 

Version - 2.73-pre

Thanks Millie!

Hi Doug,
Can you post the particulars for this LOINC for my tech person?

image.png 7.9 KB • Download

Thanks!

Here is the LOINC submission spreadsheet for all the monkeypox tests we got codes for.
Riki

CompletedTermReport_6435.xlsx 78 KB • Download

Thanks, Riki!

Thanks Riki!
Is it known how the antibody testing will be used?

All of the PCR are Detected/Not Detected results (equivocal and indeterminate also)?

thanks!

yes those are the example result values I was provided - I believe that indeterminate or equivocal could also be used (but I didn't get to see the SOP).

the antibody testing is performed at CDC - I am not sure of the indication for sending samples for that test, though some PHLs were asking as they got those as results back from CDC.
Sorry to not be of more help with this one.  - Jasmine or Rebecca may have more insights here.

Riki

Hi all - Quest's change for their analyte LOINC change should start appearing in a week or so per Wendy. They just got the download from Regenstrief and then upload it into their LIS. So just an FYI.

Thanks!